Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is in...

Protozoan Parasites and Type I IFNs

For many years, the role of interferon (IFN)-I has been characterized primarily in the context of viral infections. However, regulatory functions mediated by IFN-I have also been described against bacterial infections and in tumor immunology. Only recently, the interest in understanding the immune functions mediated by IFN-I has dramatically increased in the field of protozoan infections. In th...

Type I-IFNs control GVHD and GVL responses after transplantation.

Although the effects of type II-IFN (IFN-γ) on GVHD and leukemia relapse are well studied, the effects of type I-interferon (type I-IFN, IFN-α/β) remain unclear. We investigated this using type I-IFN receptor-deficient mice and exogenous IFN-α administration in established models of GVHD and GVL. Type I-IFN signaling in host tissue prevented severe colon-targeted GVHD in CD4-dependent models of...

Type I IFNs in the generation of antitumor immune responses

2 4 0 4 jci.org Volume 126 Number 7 July 2016 Introduction The observation of spontaneous T cell responses against tumors suggests that endogenous adjuvants might provide signals for activation of antigen presenting cells (APCs). Pattern recognition receptors (PRRs) expressed by APCs typically recognize molecular entities derived from infectious agents, which trigger innate immune responses but...

Differentiation of Dendritic Cells Type I IFNs Enhance the Terminal